There are many theories that the Roboenza virus may have some relation with the Evil Energy and the Maverick Virus, but there is no official confirmation of a connection with them.The Roboenza is a portmanteau of 'robot' and ' Influenza'.

Wily of all the instances where Mega Man had to save Wily from himself. Light alludes to Roboenza in Sonic the Hedgehog #250 when reminding Dr. Roboenza was alluded to in Mega Man #20 when Mega Man and Bass were stuck in a time loop nearing the climax of the issue. In the end of the story it's said Bass was cured after defeating Wily. Wilys damaged UFO is caught from crash-landing by Mega Man outside Dr. Later in the story, both Bass and Treble felt ill and Treble gave Bass a medicine, but when seeing Treble's state, Bass decided to shove the medicine down Treble's throat to cure him, and he faced Wily ill, causing Bass to go berserk (since all robots infected with Roboenza go berserk after one month of being ill). Several robots become berserk and attack cities across the world.

Mega Man and Proto Man go after the eight bosses to obtain chips with data for the medicine-making machine, and as Bass had defeated them before their arrival, they only had to take the chips. In the manga Rockman 10 -Extra F-, which is based on Bass' story from the game, Roll became ill with Roboenza. Bass and Treble with Roboenza in Rockman 10 -Extra F.

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